Head coach Paul Grayson told the club website: "Stephen Myler has a chance to play at 10. He is a very exciting prospect and I am looking forward to watching him play.
"There will be no league points or cup qualification to play for on Saturday, but bragging rights are worth just as much."
Robbie Kydd moves to inside centre with Seamus Mallon at 13. In the pack, Mark Easter has moved to blindside with Daniel Browne at No.8 and Sam Harding back in the No.7 shirt.
Tigers have already qualified for the semi-finals and will learn their fate in the draw on Sunday afternoon, while Saints lost their opening game against Worcester before going down to defeat at Newport Gwent Dragons.
Saturday's game kicks off at 3pm and Saints report just 400 tickets remain unsold.
Northampton Saints (v Tigers at Franklin's Gardens, Saturday 3pm)
15 Vaughan Going
14 Matthieu Bourret
13 Seamus Mallon
12 Robbie Kydd
11 Paul Diggin
10 Stephen Myler
9 Ian Vass
1 Soane Tonga'uhia
2 Dan Richmond
3 Pat Barnard
4 Matt Lord (capt)
5 David Gerard
6 Mark Easter
7 Sam Harding
8 Daniel Browne
Replacements
16 Dylan Hartley
17 Chris Budgen
18 Damien Browne
19 Ben Lewitt
20 Johnny Howard
21 Luke Myring
22 Chris Wyles
