Director of rugby Richard Cockerill includes Mathew Tait – a late withdrawal last week with injury – and Ben Woods comes into the back row with Julian Salvi switching to the No8 shirt.
Thomas Waldrom, who was withdrawn with a slight groin injury in the closing stages of the defeat by Exeter Chiefs in Round One, is named among the replacements.
Graham Kitchener is back to full fitness after injury and the lock joins the matchday squad for the first time since his summer move from Worcester Warriors. Fly-half Jeremy Staunton is also included on his return from injury.
“I thought we played some pretty good stuff in parts against Exeter last week but we made some costly errors,” said Cockerill.
“We knew this period was not going to be easy and we just have to battle through it.”
Tigers have 11 players on international duty at the Rugby World Cup and are also without the injured Craig Newby, Jordan Crane, Geoff Parling and Julian White.
Leicester Tigers (v London Wasps, away, Sunday 2.15pm)
15 Scott Hamilton
14 Matt Smith
13 Billy Twelvetrees
12 Anthony Allen
11 Mathew Tait
10 George Ford
9 James Grindal
1 Boris Stankovich
2 George Chuter (c)
3 Kieran Brookes
4 Ed Slater
5 George Skivington
6 Steve Mafi
7 Ben Woods
8 Julian Salvi
Replacements
16 Rob Hawkins
17 Jonny Harris
18 Peter Bucknall
19 Graham Kitchener
20 Thomas Waldrom
21 Mickey Young
22 Jeremy Staunton
23 Niall Morris
Wasps director of rugby Dai Young retains the same starting line-up that beat champions Saracens last weekend. The replacements include former All Black international Ross Filipo and Joe Burton who comes in for Billy Vunipola.
London Wasps
15 Hugo Southwell
14 Tom Varndell
13 Chris Bell
12 Riki Flutey
11 Christian Wade
10 Nicky Robinson
9 Charlie Davies
1 Tim Payne
2 Rob Webber
3 Ben Broster
4 Richard Birkett
5 Marco Wentzel
6 Joe Launchbury
7 Jonathan Poff
8 John Hart (c)
Replacements:
16 Nathan Morris
17 Jeremy Castex
18 Bob Baker
19 Ross Filipo
20 Joe Burton
21 Nic Berry
22 Ryan Davis
23 Richard Haughton
