Second-rower Parling is the most experienced member of a youthful squad for the first Anglo-Welsh fixture of the season.
Rob Hawkins makes his first start of the campaign alongside props Jonny Harris and Ryan Bower, and England Saxons lock Graham Kitchener starts alongside Parling.
Ben Pienaar makes his first start since injury drew his 2010/11 season to a premature close, joining Tom Armes, a try-scorer against the Ospreys in Tigers’ last visit to Wales in this competition, and Ed Slater in the back row.
Sam Harrison and Niall Morris retain their places in the backline and there is a first-team return for George Ford and Andy Forsyth.
Academy prospect Alex Lewington is included on the wing, with centre Andy Symons making his Tigers debut after a spell in club rugby in New Zealand.
The squad also includes Ed Rolston and Dante Mama who have played with Loughborough Students and the Tigers Development XV.
George Skivington returns from injury to take a place among the replacements and Richard de Carpentier could make his Tigers debut from the bench.
Leicester Tigers (v Scarlets, Parc Y Scarlets, Friday 7.45pm)
15 Niall Morris
14 Ed Rolston
13 Andy Forsyth
12 Andy Symons
11 Alex Lewington
10 George Ford
9 Sam Harrison
1 Jonny Harris
2 Rob Hawkins
3 Ryan Bower
4 Graham Kitchener
5 Geoff Parling (c)
6 Ben Pienaar
7 Tom Armes
8 Ed Slater
Replacements
16 Tom Youngs
17 Peter Bucknall
18 Fraser Balmain
19 George Skivington
20 Richard De Carpentier
21 James Grindal
22 Jeremy Staunton
23 Dante Mama
Scarlets: 15 Daniel Evans, 14 Liam Williams, 13 Rhodri Gomer Davies, 12 Adam Warren, 11 Dale Ford, 10 Aled Thomas, 9 Ruki Tipuna, 1 Phil John, 2 Kirby Myhill, 3 Rhodri Jones, 4 Dominic Day 5 Damian Welch 6 Matt Gilbert, 7 Johnathan Edwards, 8 Kieran Murphy.
Replacements: 16 Simon Gardner, 17 Craig Hawkins, 18 Peter Edwards, 19 Sione Timani, 20 Richie Pugh, 21 Aled Davies, 22 Jordan Williams, 23 Lee Rees
