Two-time European champions Tigers will make their 105th appearance in Europe’s premier club knockout competition.
Geordan Murphy will lead out a team showing three changes from the line-up which started against London Irish last weekend.
Dan Cole returns to the front row, with Martin Castrogiovanni set to make his 50th Heineken Cup appearance from among the replacements.
In the backline, this season’s top try-scorer Niall Morris replaces Scott Hamilton, and Andy Forsyth comes into the centre in place of Horacio Agulla.
Argentina international Agulla suffered a hand injury in the match against London Irish and joins Mathew Tait, Manu Tuilagi, Anthony Allen and Billy Twelvetrees on the sidelines.
Micky Young and Steve Mafi return to the matchday squad after coming through last Monday’s Development XV match in the Aviva Premiership Rugby ‘A’ League.
There is live coverage on the red button on Sky Sports 1 and BBC Radio Leicester will have live on commentary on FM, DAB and online (UK only).
Leicester Tigers (v Aironi Rugby, Stadio Brianteo, Saturday 2.30pm local time)
15 Geordan Murphy (c)
14 Niall Morris
13 Matt Smith
12 Andy Forsyth
11 Alesana Tuilagi
10 Toby Flood
9 Sam Harrison
1 Marcos Ayerza
2 George Chuter
3 Dan Cole
4 Louis Deacon
5 Geoff Parling
6 Tom Croft
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Tom Youngs
17 Boris Stankovich
18 Martin Castrogiovanni
19 George Skivington
20 Steve Mafi
21 Micky Young
22 Jeremy Staunton
23 Scott Hamilton
Aironi Rugby: 15. Ruggero Trevisan, 14. Sinoti Sinoti, 13. Andrea Masi, 12. Matteo Pratichetti, 11. Giovanbattista Venditti, 10. Luciano Orquera, 9. Tyson Keats, 1. Salvatore Perugini, 2. Fabio Ongaro, 3. Fabio Staibano, 4. Quintin Geldenhuys, 5. Marco Bortolami, 6. Nicola Cattina, 7. Simone Favaro, 8. Frans Viljoen
Replacements: 16. Roberto Santamaria, 17. Matias Aguero, 18. Lorenzo Romano, 19. Josh Sole, 20. Filippo Ferrarini, 21. Giorgio Bronzini, 22. Naas Olivier, 23. Gilberto Pavan,
