With three Aviva Premiership fixtures scheduled in a 12-day spell, director of rugby Richard Cockerill brings Hamilton and Twelvetrees into the backline, while Ed Slater and Ben Woods are given starting places among the forward pack.
Louis Deacon captains the team in the absence of Geordan Murphy, while the recall for Twelvetrees allows Manu Tuilagi to revert to outside centre, with Matt Smith replacing Alesana Tuilagi on the wing.
Micky Young is named among the replacements after proving his recovery from injury in a run of appearances in the Aviva Premiership ‘A’ League.
“We’ve got three big games in the next two weeks and we need to keep picking up points,” said director of rugby Cockerill.
“In the last five weeks we’ve come through some massive games in the Aviva Premiership and in Europe, but now our focus is entirely on Worcester. We cannot afford a let-up in the intensity we’ve shown recently.”
Tuesday's game is a sell-out at Sixways. You can stay in touch with live scoring on the Tigers official website home page, or via Facebook and Twitter. The game is also being shown live by ESPN.
Tigers return to Welford Road for back-to-back home fixtures against Sale Sharks (January 1) and London Wasps (January 7) after this week’s trip to Sixways. Tickets for both home fixtures are available now from the Tigers ticket office. Phone 0844 856 1880, call in at Welford Road or book online.
Leicester Tigers (v Worcester Warriors, Aviva Premiership Rugby, away, Tuesday 2pm)
15 Scott Hamilton
14 Horacio Agulla
13 Manu Tuilagi
12 Billy Twelvetrees
11 Matt Smith
10 Toby Flood
9 Ben Youngs
1 Boris Stankovich
2 George Chuter
3 Dan Cole
4 Louis Deacon (c)
5 Ed Slater
6 Tom Croft
7 Ben Woods
8 Thomas Waldrom
Replacements
16 Rob Hawkins
17 Martin Castrogiovanni
18 Julian White
19 Steve Mafi
20 Julian Salvi
21 Micky Young
22 Jeremy Staunton
23 Niall Morris
Worcester Warriors
15 Chris Pennell (c)
14 Marcel Garvey
13 Alex Grove
12 Dale Rasmussen
11 Miles Benjamin
10 Joe Carlisle
9 Shaun Perry
1 Matt Mullan
2 Ed Shervington
3 Tevita Taumoepeau
4 James Percival
5 Craig Gillies
6 Sam Betty
7 Jake Abbott
8 Chris Jones
Replacements
16 Bruce Douglas
17 Aleki Lutui
18 Oliver Tomaszczyk
19 Ben Gulliver
20 Matt Kvesic
21 Jonny Arr
22 Andy Goode
23 Ravai Fatiaki
