Fly-half Flood came through half an hour of last weekend’s win over Newcastle Falcons following his recovery from a knee injury, while centre Tuilagi is included for the first time since suffering a hamstring injury in the victory at Worcester at the end of December.
Skipper Geordan Murphy, wing Alesana Tuilagi and back-rower Julian Salvi are among those who return after sitting out the cup action in the last fortnight.
Fly-half George Ford, who captained England Under-20s to victory over Scotland last weekend, returns to club duty and is named among the replacements.
Director of rugby Richard Cockerill said: “It’s good to have Toby and Manu back to fitness. This is an important phase of the season for us. We’ve been in good form and we obviously need to maintain that.
“Exeter are a tough, physical side and hard to beat, and we see ourselves as a tough side who are also hard to beat so it should be a really good game.”
Leicester Tigers (v Exeter Chiefs, Sandy Park, Saturday 6.00pm)
15 Geordan Murphy (c)
14 Horacio Agulla
13 Manu Tuilagi
12 Anthony Allen
11 Alesana Tuilagi
10 Toby Flood
9 Sam Harrison
1 Marcos Ayerza
2 George Chuter
3 Julian White
4 Ed Slater
5 George Skivington
6 Steve Mafi
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Rob Hawkins
17 Boris Stankovich
18 Logoviii Mulipola
19 Graham Kitchener
20 Ben Woods
21 James Grindal
22 George Ford
23 Matt Smith
Exeter Chiefs
15 Phil Dollman
14 Gonzalo Camacho
13 Nic Sestaret
12 Jason Shoemark
11 Matt Jess
10 Ignacio Mieres
9 Haydn Thomas
1 Brett Sturgess
2 Neil Clark
3 Hoani Tui
4 Tom Hayes (c)
5 Aly Muldowney
6 Tom Johnson
7 James Scaysbrook
8 Richard Baxter
Replacements
16 Chris Whitehead
17 Ben Moon
18 Craig Mitchell
19 James Phillips
20 Ben White
21 Kevin Barrett
22 Gareth Steenson
23 Bryan Rennie
