The 24-year-old tighthead is brought in due to the absence of internationals Dan Cole and Martin Castrogiovanni, and a one-week ban for Julian White.
Mulipola has made four appearances for the club this season, including starting the LV= Cup win over Harlequins, but makes his first league start at Vicarage Road this weekend.
Sam Harrison (ankle) and Alesana Tuilagi (knee) are ruled out after picking up injuries at Exeter Chiefs last Saturday, and are replaced by James Grindal and Matt Smith.
Manu Tuilagi, Toby Flood and Thomas Waldrom return from England's Six Nations preparations to resume their roles in the Leicester line-up.
Craig Newby, who captained Tigers in the Aviva Premiership Final against Saracens in May, is named among the replacements as he continues his return from injury.
Scotland Under-20s scrum-half Scott Steele is included in the matchday squad for the first time, joining England Under-20s fly-half George Ford among the replacements.
Leicester Tigers (v Saracens, Vicarage Road, Sunday 2.30pm)
15 Geordan Murphy (c)
14 Horacio Agulla
13 Manu Tuilagi
12 Anthony Allen
11 Matt Smith
10 Toby Flood
9 James Grindal
1 Marcos Ayerza
2 George Chuter
3 Logoviii Mulipola
4 Ed Slater
5 George Skivington
6 Steve Mafi
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Rob Hawkins
17 Boris Stankovich
18 Ryan Bower
19 Graham Kitchener
20 Craig Newby
21 Scott Steele
22 George Ford
23 Scott Hamilton
Saracens make just two changes to their line-up with Schalk Brits and Neil de Kock starting the game after making a return from injury as replacements against Wasps last weekend. Matt Stevens is named on the bench after being released by England and Ben Spencer also returns from duty with England Under-20s.
Saracens
15 Alex Goode
14 Duncan Taylor
13 Chris Wyles
12 Adam Powell
11 James Short
10 Nils Mordt
9 Neil de Kock
1 John Smit (c)
2 Schalk Brits
3 Carlos Nieto
4 George Kruis
5 Hayden Smith
6 Justin Melck
7 Andy Saull
8 Jackson Wray
Replacements
16 Jamie George
17 Rhys Gill
18 Matt Stevens
19 Hugh Vyvyan
20 Will Fraser
21 Ben Spencer
22 Joel Tomkins
23 Michael Tagicakibau
