The England duo have been released from international duty and will start for Tigers in the Round 17 encounter.
Samoan wing Alesana Tuilagi, joint top try-scorer this season and the top scorer in the Aviva Premiership last season, returns after a two-week absence.
The only other change to the team which recorded a bonus-point victory over Newcastle Falcons last weekend is in the second row where Graham Kitchener starts.
Tickets are available now from the Tigers ticket office and from the Club Store in Market Street, Leicester. Phone 0844 856 1880, call in or book online. The ticket office is open until 5pm Friday, 9am-5pm Saturday and from 9am Sunday.
Leicester Tigers (vs Gloucester, Aviva Premiership Rugby, Welford Road, Sunday 1pm)
15 Geordan Murphy (c)
14 Horacio Agulla
13 Matt Smith
12 Billy Twelvetrees
11 Alesana Tuilagi
10 Toby Flood
9 Ben Youngs
1 Marcos Ayerza
2 George Chuter
3 Logoviii Mulipola
4 George Skivington
5 Graham Kitchener
6 Steve Mafi
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Rob Hawkins
17 Boris Stankovich
18 Julian White
19 Ben Pienaar
20 Craig Newby
21 James Grindal
22 George Ford
23 Scott Hamilton
Centre Tim Molenaar will make his first Aviva Premiership start of the season for Gloucester and Brett Deacon starts against his former club.
Gloucester Rugby: 15 Jonny May; 14 Charlie Sharples, 13 Mike Tindall (c), 12 Tim Molenaar, 11 Tom Voyce; 10 Freddie Burns, 9 Dave Lewis; 1 Nick Wood, 2 Darren Dawidiuk, 3 Rupert Harden; 4 Will James, 5 Alex Brown; 6 Tom Savage, 7 Matt Cox, 8 Brett Deacon. Replacements: 16 Scott Lawson, 17 Dan Murphy, 18 Shaun Knight, 19 Jim Hamilton, 20 Akapusi Qera, 21 Nick Runciman, 22 Ryan Mills, 23 Ollie Phillips
