Back-rower Newby has returned to full fitness following a knee injury and has been involved in the first-team squad during the last month but makes his first start of the season on Friday.
Internationals Scott Hamilton and Horacio Agulla are included in the backline, while Alex Lewington and Andy Forsyth, who both scored tries in the vital cup win away to Harlequins in Round 3, are also given starting positions. George Ford teams up with James Grindal at half-back.
Rob Hawkins lines up at hooker against his former club, and Tom Youngs returns after injury to take a place among the replacements alongside international front-rowers Marcos Ayerza and Logoviii Mulipola, and England Elite Player Squad member Thomas Waldrom.
Ticklets remain on sale for Friday. Call the Bath ticket office on 0844 448 1865.
Friday's game will be shown live on Sky Sports 3.
Or keep in touch with the Tigers Facebook and Twitter pages.
Leicester Tigers (v Bath Rugby, The Recreation Ground, Friday 7.30pm)
15 Scott Hamilton
14 Horacio Agulla
13 Andy Forsyth
12 Billy Twelvetreees
11 Alex Lewington
10 George Ford
9 James Grindal
1 Boris Stankovich
2 Rob Hawkins
3 Julian White
4 Calum Green
5 Graham Kitchener
6 Steve Mafi
7 Craig Newby (c)
8 Ben Pienaar
Replacements
16 Tom Youngs
17 Marcos Ayerza
18 Logoviii Mulipola
19 Julian Salvi
20 Thomas Waldrom
21 Scott Steele
22 Jeremy Staunton
23 Matt Smith
Bath Rugby:
15 Sam Vesty
14 Matt Banahan
13 Matt Carraro
12 Olly Barkley
11 Tom Biggs
10 Tom Heathcote
9 Michael Claassens
1 Charlie Beech
2 Lee Mears
3 Duncan Bell
4 Dave Attwood
5 Ryan Caldwell
6 Ben Skirving
7 Francois Louw (c)
8 Simon Taylor
Replacements
16 Pieter Dixon
17 David Flatman
18 Anthony Perenise
19 Guy Mercer
20 Carl Fearns
21 Chris Cook
22 Olly Woodburn
23 Jack Cuthbert
