Leicester Tigers prop Ayerza will start in the front row for the Pumas alongside Eusebio Guinazu and Juan Figallo, while Felipe Contepomi comes in at centre. Former Tigers wing Horacio Agulla is named among the substitutes.
Meanwhile, Steve Mafi and Martin Castrogiovanni could come face-to-face when Italy host Tonga in Brescia on Saturday. Mafi, who wins his seventh cap, will start on the blindside flank for Tonga while Castrogiovanni will hope to add to his 88 international appearances from the bench.
Argentina:
15 Juan Martin Hernandez
14 Gonzalo Camacho
13 Gonzalo Tiesi
12 Felipe Contepomi
11 Juan Imhoff
10 Nicolas Sanchez
9 Martin Landajo
1 Marcos Ayerza
2 Eusebio Guinazu
3 Juan Figallo
4 Manuel Carizza
5 Julio Farias Cabello
6 Leonardo Senatore
7 Juan Manuel Leguizamon
8 Juan Martin Fernandez Lobbe
Replacements: 16 Agustin Creevy, 17 Bruno Postiglioni, 18 Juan Gomez, 19 Tomas Vallejos Cinalli, 20 Tomas Leonardi, 21 Nicolas Vergallo, 22 Horacio Agulla, 23 Joaquin Tuculet
Italy
15 Andrea Masi
14 Tommaso Iannone,
13 Tommaso Benvenuti
12 Alberto Sgarbi
11 Luke McLean
10 Kristopher Burton
9 Tobias Botes
1 Andrea Lo Cicero
2 Leonardo Ghiraldini
3Lorenzo Cittadini
4 Quintin Geldenhuys
5 Joshua Furno
6 Alessandro Zanni
7 Robert Barbieri
8 Sergio Parisse
Replacements: 16 Davide Giazzon, 17 Alberto De Marchi, 18 Martin Castrogiovanni, 19 Antonio Pavanello, 20 Simone Favaro, 21 Edoardo Gori, 22 Luciano Orquera, 23 Giovambattista Venditti
Tonga:
15 Vungakoto Lilo
14 Fetu'u Vainikolo
13 Sukanaivalu Hufanga
12 Sione Piukala
11 Viliami Helu
10 Fangatapu 'Apikotoa
9 Taniela Moa (c)
1 'Alisona Taumalolo
2 Elvis Taione
3 Halani 'Aulika
4 Joe Tu'ineau
5 Tukulua Lokotui
6 Sitiveni Mafi
7 Sione Vaiomo'unga
8 Viliami Ma'afu
Replacements: 16 Ilaisa Ma'asi, 17 Tevita Mailau, 18 Hale T-Pole, 19 Paula Kaho, 20 Samisoni Fisilau, 21 Alipate Fatafehi, 22 Viliame ‘longi, 23 Soane Tonga'uiha
