Tigers centre Allen missed the home win over Treviso in Round 3 after injury in the Aviva Premiership match against Bath a week earlier.
Niall Morris and Adam Thompstone return on the wings, while Dan Cole, Louis Deacon and Brett Deacon are recalled into the forward pack.
Logovi’i Mulipola is selected among the replacements on his return from injury.
Saturday’s match in Treviso – a third visit to the Stadio Monigo in the last three years – is a 2.35pm kick-off local time (1.35pm UK time). Live TV coverage is available on Sky Sports 1 via the red button.
Leicester Tigers (v Benetton Treviso, away, Saturday 2.35pm local/1.35pm UK)
15 Mathew Tait
14 Niall Morris
13 Manusamoa Tuilagi
12 Anthony Allen
11 Adam Thompstone
10 George Ford
9 Ben Youngs
1 Marcos Ayerza
2 Tom Youngs
3 Dan Cole
4 Louis Deacon (c)
5 Geoff Parling
6 Brett Deacon
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 George Chuter
17 Logovi’i Mulipola
18 Martin Castrogiovanni
19 Graham Kitchener
20 Jordan Crane
21 Sam Harrison
22 Geordan Murphy
23 Dan Bowden
Benetton Treviso: Luke McLean; Ludovico Nitoglia, Christian Loamanu, Alberto Sgarbi, Tommaso Iannone; Alberto Di Bernardo, Edoardo Gori; Michele Rizzo, Leonardo Ghiraldini (c), Lorenzo Cittadini, Francesco Minto, Corniel Van Zyl, Alessandro Zanni, Dean Budd, Manoa Vosawai.
Replacements: Franco Sbaraglini, Matteo Muccignat, Ignacio Fernandez-Rouyet, Valerio Bernabo, Paul Derbyshire, Simone Favaro, Fabio Semenzato, Kristopher Burton.
