England players Tom Youngs, Dan Cole, Geoff Parling, Tom Croft, Ben Youngs, Toby Flood and Manu Tuilagi all return to the Tigers starting line-up for the trip to Devon.
Martin Castrogiovanni, who captained Italy during this season’s Six Nations and now has 95 Test caps, is also in the 23-man squad.
Tigers director of rugby Richard Cockerill said: “It’s great to have everyone back for the start of the run-in, we’ve had a good week back together this week and now we just want to get back out on the field.
“Exeter have a very good record at home but every game from now until the end of the season is massive for us and we have to get it right.”
Fly-half Flood will lead out Tigers as captain for the first time in the absence of both Geordan Murphy and Louis Deacon.
Steve Mafi is unavailable this week due to injury, while Boris Stankovich and Miles Benjamin are also sidelined.
Saturday’s match is a sell-out at Sandy Park. The game is being covered live by ESPN.
Tigers will wear the away blue kit for Saturday's game.
Leicester Tigers (v Exeter Chiefs, away, Saturday 5pm)
15 Mathew Tait
14 Niall Morris
13 Manusamoa Tuilagi
12 Anthony Allen
11 Adam Thompstone
10 Toby Flood (c)
9 Ben Youngs
1 Marcos Ayerza
2 Tom Youngs
3 Dan Cole
4 Ed Slater
5 Geoff Parling
6 Tom Croft
7 Julian Salvi
8 Jordan Crane
Replacements
16 Rob Hawkins
17 Logovi’i Mulipola
18 Martin Castrogiovanni
19 Thomas Waldrom
20 Graham Kitchener
21 Sam Harrison
22 George Ford
23 Matt Smith
Exeter Chiefs
15 Luke Arscott
14 Jack Nowell
13 Sireli Naqelevuki
12 Phil Dollman
11 Matt Jess
10 Gareth Steenson
9 Haydn Thomas
1 Carl Rimmer
2 Jack Yeandle
3 Hoani Tui
4 Dean Mumm
5 Damian Welch
6 Ben White
7 James Scaysbrook
8 Richard Baxter (c)
Replacements
16 Chris Whitehead
17 Brett Sturgess
18 Craig Mitchell
19 James Hanks
20 Dave Ewers
21 Will Chudley
22 Henry Slade
23 Ian Whitten
