England face France at the Stade Henri Desgrange in La Roche-sur-Yon on Wednesday (kick-off 5.45pm GMT). The game is live on Sky Sports.
Price and Purdy, who both made their Tigers first-team debuts in last season's LV= Cup, take their place on the bench. Harlequins back-rower Jack Clifford captains the team.
Head coach Nick Walshe said: “It’s a massive challenge playing against France, particularly in France, but it’s a challenge we’re relishing.
“We obviously played them in the Six Nations and put in a good performance, but this is a different game – we won’t be complacent, we’ll be treating them with the respect they deserve.
“The lads have trained well for the first couple of days – they’re looking good but to be honest they just want to get out there and play.”
England Under 20 starting XV to play France
15 Ollie Devoto (Bath Rugby)
14 Anthony Watson (Bath Rugby)
13 Harry Sloane (Harlequins)
12 Sam Hill (Exeter Chiefs)
11 Ben Howard (Worcester Warriors)
10 Henry Slade (Exeter Chiefs)
9 Callum Braley (Bristol Rugby)
1 Alec Hepburn (London Wasps)
2 Luke Cowan-Dickie (Exeter Chiefs)
3 Scott Wilson (Newcastle Falcons)
4 Elliott Stooke (Gloucester Rugby)
5 Dominic Barrow (Leeds Carnegie)
6 David Sisi (Bath Rugby)
7 Matt Hankin (Saracens)
8 Jack Clifford (Harlequins) (c)
Replacements
16 Nathan Morris (London Wasps)
17 Danny Hobbs-Awoyemi (Northampton Saints)
18 Tom Smallbone (London Irish)
19 Tom Price (Leicester Tigers)
20 Ross Moriarty (Gloucester Rugby)
21 Alex Day (Northampton Saints)
22 Henry Purdy (Leicester Tigers)
23 Jack Nowell (Exeter Chiefs)
