Wells and Price, who made their Tigers first-team debuts in the LV= Cup last season, will be joined by Leicester teammate Henry Purdy on Thursday (kick-off 5.45pm BST).
Purdy, who was on the mark in England’s 31-24 defeat to South Africa last time out, starts on the wing at the Stade Henri Desgrange in La Roche-sur-Yon.
With a semi-final spot still up for grabs, England need to ensure a bonus-point victory to stand any chance of progressing.
England Under 20 starting XV against USA
15 Ollie Devoto (Bath Rugby)
14 Ben Howard (Worcester Warriors)
13 Tom Stephenson (Northampton Saints)
12 Harry Sloan (Harlequins)
11 Henry Purdy (Leicester Tigers)
10 Will Hooley (Northampton Saints)
9 Alex Day (Northampton Saints) (c)
1 Alec Hepburn (London Wasps)
2 Scott Spurling (Saracens)
3 Tom Smallbone (London Irish)
4 Harry Wells (Leicester Tigers)
5 Tom Price (Leicester Tigers)
6 Ross Moriarty (Gloucester Rugby)
7 Joel Conlon (Exeter Chiefs)
8 David Sisi (Bath Rugby)
Replacements:
16 Nathan Morris (London Wasps)
17 Danny Hobbs-Awoyemi (Northampton Saints)
18 Scott Wilson (Newcastle Falcons)
19 Dominic Barrow (Leeds Carnegie)
20 Jack Clifford (Harlequins)
21 Callum Braley (Bristol Rugby)
22 Henry Slade (Exeter Chiefs)
23 Jack Nowell (Exeter Chiefs)
