Uncapped forward Slater and scrum-half Youngs are among 10 players made available to their clubs following England training on Tuesday.
England head coach Stuart Lancaster has named an unchanged 23-man squad to travel to Edinburgh for the RBS 6 Nations match against Scotland, with Tigers forwards Dan Cole and Tom Youngs retaining their places. The team will be named on Thursday.
Lancaster said: "We were disappointed by the result against France but very proud of many aspects of the performance and we want to give the same 23 the opportunity to build on that.
"All the squad have been excellent in training over the last two days and I know those going back to play for their Aviva Premiership clubs will be determined to put a marker down for the subsequent matches."
England squad
Forwards
David Attwood (Bath Rugby)
Dan Cole (Leicester Tigers)
Dylan Hartley (Northampton Saints)
Joe Launchbury (London Wasps)
Courtney Lawes (Northampton Saints)
Joe Marler (Harlequins)
Ben Morgan (Gloucester Rugby)
Chris Robshaw (Harlequins)
Henry Thomas (Sale Sharks)
Billy Vunipola (Saracens)
Mako Vunipola (Saracens)
Tom Wood (Northampton Saints)
Tom Youngs (Leicester Tigers)
Backs
Brad Barritt (Saracens)
Mike Brown (Harlequins)
Luther Burrell (Northampton Saints)
Danny Care (Harlequins)
Lee Dickson (Northampton Saints)
Owen Farrell (Saracens)
Alex Goode (Saracens)
Jonny May (Gloucester Rugby)
Jack Nowell (Exeter Chiefs)
Billy Twelvetrees (Gloucester Rugby)
Returning to Aviva Premiership clubs:
Chris Ashton (Saracens)
Freddie Burns (Gloucester Rugby)
Kyle Eastmond (Bath Rugby)
George Ford (Bath Rugby)
Matt Kvesic (Gloucester Rugby)
Tom Johnson (Exeter Chiefs)
Matt Mullan (London Wasps)
Ed Slater (Leicester Tigers)
Anthony Watson (Bath Rugby)
Ben Youngs (Leicester Tigers)
