Leicester Tigers wing Scully wins his 16th Test cap for the USA, with a place in the World Cup in England next year potentially just 160 minutes away.
The USA are in Montevideo for the first leg, with the return on home soil next Saturday.
The Eagles have lost to Uruguay once in 12 games, back in 2002 in Montevideo. Since then, they have a plus-129 point differential in six wins, with the most recent being a two-leg series win ahead of the IRB Rugby World Cup 2011.
Watch the first leg of the IRB Rugby World Cup 2015 Qualifier play-off between the Eagles and Uruguay live from Estadio Charrua on the IRB Live website (kick-off 7pm UK time).
USA Eagles
15 Chris Wyles
14 Blaine Scully
13 Folau Niua
12 Andrew Suniula
11 Tim Maupin
10 Toby L'Estrange
9 Mike Petri
1 Olive Kilifi
2 Phil Thiel
3 Eric Fry
4 Hayden Smith
5 Samu Manoa
6 Todd Clever (c)
7 Scott LaValla
8 Cam Dolan
Replacements
16 Tom Coolican
17 Nick Wallace
18 Titi Lamositele
19 Louis Stanfill
20 Kyle Sumsion
21 Shalom Suniula
22 Seamus Kelly
23 Luke Hume
