Ospreys coach Sean Holley said: Everybody within the camp is looking forward to renewing what has become a healthy rivalry with Leicester. They've made a good start to the season and we know that we can expect a real test.
We see Welford Road as being a great place to start this year's campaign, there will be a great atmosphere there as always.
"We have made a very positive start to our own season and are starting to see the fruits of the players hard work during pre-season.
Like all professional rugby outfits, we have had injuries to contend with, but the squad is in very good shape and we are ready for the challenge.
Centre Sonny Parker has been ruled out by an injury picked up in the win over Harlequins last weekend, while fellow international Mike Phillips is continuing his rehab following knee surgery. Gavin Henson has been left out.
Ospreys (v Leicester Tigers, Welford Road, Sunday 1pm)
15 Lee Byrne
14 Nikki Walker
13 Tommy Bowe
12 Andrew Bishop
11 Shane Williams
10 James Hook
9 Rhodri Wells
1 Paul James
2 Richard Hibbard
3 Adam Jones
4 Alun-wyn Jones
5 Ian Evans
6 Jonathan Thomas
7 Marty Holah
8 Ryan Jones (c)
Replacements
16 Huw Bennett
17 Duncan Jones
18 Ian Gough
19 Filo Tiatia
20 Tom Smith
21 Rhys Webb
22 Daniel Biggar
