Youngs missed the bonus-point win over Worcester Warriors in the team’s last outing as he served a one-week suspension and he is re-united with international colleague Toby Flood at half-back.
Horacio Agulla, George Skivington and Geoff Parling are included in the team after missing the Worcester fixture.
Tigers director of rugby Richard Cockerill said: “Tigers versus Saints is always a big match, no matter what is at stake. Both teams are chasing a place in the semi-finals and this promises to be another big occasion. These are two good set-piece teams, with two good sets of backs, and these games have been great contests.”
Leicester Tigers (v Northampton Saints, Aviva Premiership Rugby, Franklin’s Gardens, Saturday 2.15pm)
15 Geordan Murphy (c)
14 Horacio Agulla
13 Manusamoa Tuilagi
12 Anthony Allen
11 Alesana Tuilagi
10 Toby Flood
9 Ben Youngs
1 Marcos Ayerza
2 George Chuter
3 Dan Cole
4 George Skivington
5 Geoff Parling
6 Tom Croft
7 Julian Salvi
8 Thomas Waldrom
Replacements
16 Tom Youngs
17 Martin Castrogiovanni
18 Logovi’i Mulipola
19 Steve Mafi
20 Craig Newby
21 Sam Harrison
22 Billy Twelvetrees
23 Scott Hamilton
Northampton Saints
15 Ben Foden
14 Chris Ashton
13 George Pisi
12 James Downey
11 Paul Diggin
10 Ryan Lamb
9 Lee Dickson (c)
1 Soane Tonga’uiha
2 Andy Long
3 Brian Mujati
4 Samu Manoa
5 Christian Day
6 James Craig
7 Phil Dowson
8 Roger Wilson
Replacements
16 Ross McMillan
17 Alex Waller
18 Paul Doran Jones
19 Mark Sorenson
20 Ben Nutley
21 Martin Roberts
22 Stephen Myler
23 Tom May