Club captain Murphy lines up at full-back in his 322nd appearance for the club, while Castrogiovanni is named in the front row.
There is also a change on the wing as Vereniki Goneva comes into the line-up.
All six Tigers named in the British & Irish Lions squad earlier this week are included in the matchday 23, with starting places for Manu Tuilagi, Ben Youngs, Tom Youngs, Geoff Parling and Tom Croft, and Dan Cole among the replacements..
Saturday’s match is heading towards a 24,000 sell-out at Welford Road with the last 200 tickets on sale now. Phone the Tigers ticket office on 0844 856 1880 or call in at Welford Road (open until 5pm Friday and from 9am on Saturday). Or book online now and collect on the way to the game.
This game is not scheduled for any live TV coverage so the only way to see all of the action is at Welford Road.
Leicester Tigers (v London Irish, Welford Road, Saturday 2.30pm)
15 Geordan Murphy (c)
14 Niall Morris
13 Manusamoa Tuilagi
12 Anthony Allen
11 Vereniki Goneva
10 Toby Flood
9 Ben Youngs
1 Logovi’i Mulipola
2 Tom Youngs
3 Martin Castrogiovanni
4 Graham Kitchener
5 Geoff Parling
6 Tom Croft
7 Julian Salvi
8 Jordan Crane
Replacements
16 Rob Hawkins
17 Fraser Balmain
18 Dan Cole
19 Steve Mafi
20 Thomas Waldrom
21 Sam Harrison
22 George Ford
23 Mathew Tait
London Irish
15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Guy Armitage, 11 Marland Yarde, 10 Ian Humphreys, 9 Darren Allinson; 1 Alex Corbisiero, 2 Scott Lawson, 3 Halani Aulika, 4 George Skivington (c), 5 Bryn Evans, 6 Matt Garvey, 7 Jamie Gibson, 8 Ofisa Treviranus.
Replacements: 16 David Paice, 17 Jerry Yanuyanutawa, 18 Leo Halavatau, 19 Kieran Low, 20 Jebb Sinclair, 21 Declan Danaher, 22 Shane Geraghty, 23 Jack Moates
