England internationals Tait and Cole were both among the replacements for last weekend’s bonus-point win over London Irish but reclaim their starting spots for Saturday.
Toby Flood will lead out the team as captain for the club’s ninth successive appearance in the Premiership semi-finals.
Director of rugby Richard Cockerill said: “We’ve been in good form and had some good momentum in the run-in but now it is knockout rugby. It’s all about being ready and the players bringing their best game on the day against a very good Harlequins side.”
Tigers are expecting another 20,000-plus crowd for the last home game of the season. Tickets are still available from the Tigers ticket office, which is open until 5pm Friday and from 9am on Saturday.
Purchase in person at Welford Road, phone the ticket office on 0844 856 1880 (option 2) or book online at the club website.
Leicester Tigers (vs Harlequins, Aviva Premiership Rugby semi-final, Welford Road, Saturday 3pm)
15 Mathew Tait
14 Niall Morris
13 Manusamoa Tuilagi
12 Anthony Allen
11 Vereniki Goneva
10 Toby Flood (c)
9 Ben Youngs
1 Logovi’i Mulipola
2 Tom Youngs
3 Dan Cole
4 Graham Kitchener
5 Geoff Parling
6 Tom Croft
7 Julian Salvi
8 Jordan Crane
Replacements
16 Rob Hawkins
17 Fraser Balmain
18 Martin Castrogiovanni
19 Steve Mafi
20 Thomas Waldrom
21 Sam Harrison
22 George Ford
23 Matt Smith
Harlequins
15 Mike Brown
14 Tom Williams
13 George Lowe
12 Tom Casson
11 Ugo Monye
10 Nick Evans
9 Danny Care
1 Joe Marler
2 Joe Gray
3 James Johnston
4 Olly Kohn
5 George Robson
6 Maurie Fa’asavalu
7 Luke Wallace
8 Nick Easter (c)
Replacements
16 Rob Buchanan
17 Mark Lambert
18 Will Collier
19 Charlie Matthews
20 Tom Guest
21 Karl Dickson
22 Ben Botica
23 Ross Chisholm
