Lock Calum Green will captain a team which shows limited few changes from the line-up that secured victory over Newport Gwent Dragons last weekend.
Will Hurrell, who came off the bench to score two tries against the Dragons, starts on the wing, while Andy Gates comes in at centre and Andy Brown returns to the front row.
The Academy will return to home ground on Wednesday evening for a match against Ospreys Under-18s (Oval Park ,7.15pm).
Leicester Tigers Academy v Leeds Carnegie (at West Park Leeds, Saturday 2pm)
Greig Tonks, Manu Tuilagi, Joe Cobden, Andy Gates, Will Hurrell, Elliott Read, Sam Harrison; Andy Brown, Jimmy Stevens, Ryan Bower, Calum Green (c), Mark Deaville, Tom Armes, Matt Everard, Seb Pearson. Reps (from): Johnny Harris, Jethro Rawling, Huw Marsden, Jack Owens, Finlay Barnham, Gareth Clarke, Connor Smith, Michael Gillick