Youngs keeps his starting spot off the back of England's 40-0 win over Georgia in the first game of the Autumn Nations Cup internationals.
Tigers fly-half George Ford is named on the bench following his return from an achilles injury that his seen him miss both victories over Italy and Georgia. Ellis Genge is also named on the bench as both teams look to build on their opening day victories.
England's backline is unchanged from the 40-0 victory against Georgia last weekend, while props Mako Vunipola and Kyle Sinckler are also back in the starting XV.
Ireland, who beat Wales 32-9 last week, have made four changes for their trip to Twickenham.
England versus Ireland is live on Amazon Prime and Channel 4 on Saturday afternoon.
15 Elliot Daly (Saracens, 44 caps)
14 Jonathan Joseph (Bath Rugby, 52 caps)
13 Ollie Lawrence (Worcester Warriors, 2 cap)
12 Henry Slade (Exeter Chiefs, 31 caps)
11 Jonny May (Gloucester Rugby, 58 caps)
10 Owen Farrell (Saracens, 85 caps) (c)
9 Ben Youngs (Leicester Tigers, 101 caps)
1 Mako Vunipola (Saracens, 60 caps)
2 Jamie George (Saracens, 51 caps)
3 Kyle Sinckler (Bristol Bears, 37 caps)
4 Maro Itoje (Saracens, 40 caps)
5 Joe Launchbury (Wasps, 66 caps)
6 Tom Curry (Sale Sharks, 25 caps)
7 Sam Underhill (Bath Rugby, 19 caps)
8 Billy Vunipola (Saracens, 53 caps)
16 Tom Dunn, (Bath Rugby, 2 cap)
17 Ellis Genge (Leicester Tigers, 20 caps)
18 Will Stuart (Bath Rugby, 5 caps)
19 Jonny Hill (Exeter Chiefs, 1 cap)
20 Ben Earl (Bristol Bears, 5 caps)
21 Dan Robson (Wasps, 4 caps)
22 George Ford (Leicester Tigers, 69 caps)
23 Max Malins (Bristol Bears, 1 cap)
Ireland: Keenan; Earls, Farrell, Aki, Lowe; R Byrne, Gibson-Park; Healy, Kelleher, Porter; Roux, Ryan (capt); Stander, O'Mahony, Doris.
Replacements: Herring, E Byrne, Bealham, Henderson, Connors, Murray, B Burns, Stockdale.