Crane, whose club form at No8 took him to a senior international debut in the autumn, started in the second row for the Saxons in a 66-0 victory over Portugal last weekend and will line-up alongside skipper George Skivington in Belfast.
Leicester colleague Harry Ellis has been named at scrum-half, though if he is required in the senior squad after being called up to cover injury to Danny Care, his Saxons place will go to Paul Hodgson of London Irish.
Tigers prop Dan Cole, who made his Saxons debut in the win over Portugal, is named among the replacements for Friday.
Saxons head coach Stuart Lancaster said: "Ireland will be a very tough opposition. With so many new players in our squad, we'll be looking to build our team on and off the field and give the players a framework in which to express and enjoy themselves, yet still achieve our ultimate aim which is to win the game."
England Saxons (v Ireland A, Donnybrook, Friday 7.35pm)
15 Nick Abendanon (Bath Rugby)*
14 Topsy Ojo (London Irish)*
13 Dominic Waldouck (London Wasps)
12 Jordan Turner-Hall (Harlequins)
11 Matt Banahan (Bath Rugby)
10 Danny Cipriani (London Wasps)*
9 Harry Ellis (Leicester Tigers)* or Paul Hodgson (London Irish)*
1 Matthew Mullan (Worcester Warriors)
2 David Paice (London Irish)*
3 Dave Wilson (Newcastle Falcons)
4 Jordan Crane (Leicester Tigers)*
5 George Skivington (London Wasps, captain)
6 Chris Robshaw (Harlequins)
7 Will Skinner (Harlequins)
8 Tom Guest (Harlequins)
16 Rob Webber (London Wasps)
17 Dan Cole (Leicester Tigers)
18 Stuart Hooper (Bath Rugby)
19 Phil Dowson (Newcastle Falcons)
20 Paul Hodgson (London Irish)* or Joe Simpson (London Wasps)
21 Stephen Myler (Northampton Saints)
22 David Strettle (Harlequins)*
* denotes senior international