The 20-year-old Leicester Tigers centre made his breakthrough with a second-half score, barging through close to the posts following an inside pass from fly-half Jonny Wilkinson.
Wales wing George North scored twice, with the visitors’ other try coming from Shane Williams, while No.8 James Haskell joined Tuilagi on the England scoresheet, powering his way over the line from a close-range scrum. Wilkinson kicked the remainder of the England points.
Tuilagi, who has already been capped by England at under-16, 18, 20 and Saxons levels, was joined in the starting line-up by Tigers colleague Tom Croft. Dan Cole, Louis Deacon, Toby Flood and Ben Youngs are also included in the 40-man training squad as England continue their preparations for the Rugby World Cup.
England: Armitage, Banahan, Tuilagi, Flutey, Cueto, Wilkinson, Care; Corbisiero, Hartley, Stevens, Shaw, Palmer, Croft, Moody (c), Haskell. Reps: Mears (for Hartley 58), Wilson (for Stevens 58), Stevens (for Corbisiero 71), Botha (for Shaw 58), Wood (for Moody 61), Wigglesworth (for Care 58), Hodgson (for Wilkinson 76), Sharples (for Tuilagi 59).
Wales: Stoddart, North, Davies, Roberts, Shane Williams, Priestland, Phillips; James, Bennett, Mitchell, Davies, AW Jones, Lydiate, Warburton (capt), Faletau. Reps: Burns (for Bennett 65), Bevington (for James 65), Charteris (for AW Jones 65), R Jones (for Faletau 55), Knoyle (for Phillips 61), Scott Williams (for Stoddart 48), Lloyd Williams.
Referee: S Walsh (ARU)