Tigers begin with a trip to The Rec to take on Bath on Saturday, October 27, kick-off 2.15pm, as they go in search of a second successive EDF crown.
Last season's double winners then host beaten semi-finalists Cardiff Blues on Saturday, November 3, kick-off 2.30pm, with that fixture being televised live on the BBC.
The defending champions' final group match will take place at Welford Road against Sale Sharks on the weekend of November 30/December ½, with the exact date and time yet be finalised.
The tournament itself kicks off on Friday, October 26 at 7.10pm, with BBC Wales showing coverage of Tigers' Group B rivals Cardiff Blues and Sale Sharks from live the Welsh capital.
EDF Energy Fixtures 2007/2008 Rounds 1 & 2
Group A Saturday, Oct 27, 5.30pm, Newport Gwent Dragons vs London Wasps, S4C
Group A Saturday, Oct 27, 3pm, Gloucester Rugby vs Newcastle Falcons
Group B Saturday, Oct 27, 2.15pm, Bath Rugby vs Leicester Tigers
Group B Friday, Oct 26, 7.10pm, Cardiff Blues vs Sale Sharks, BBC Wales
Group C Sunday, Oct 28, 3pm, London Irish vs Harlequins
Group C Saturday, Oct 27, 2.30pm, Worcester Warriors vs Ospreys, BBC One
Group D Sunday, Oct 28, 3.10pm, Bristol Rugby vs Llanelli Scarlets, BBC Wales
Group D Friday, Oct 26, 8pm, Leeds Carnegie v Saracens
Group A Sunday Nov 4, 3pm, London Wasps vs Gloucester Rugby
Group A Saturday, Nov 3, 5.30pm, Newcastle Falcons vs Newport Gwent Dragons, S4C
Group B Saturday, Nov 3, 2.30pm, Leicester Tigers vs Cardiff Blues, BBC One
Group B, Friday, Nov 2, 7.45pm, Sale Sharks vs Bath Rugby
Group C Saturday, Nov 3, 3pm, Harlequins vs Worcester Warriors
Group C Sunday, Nov 4, 4.10pm, Ospreys vs London Irish, S4C
Group D Friday, Nov 2, 7.10pm, Llanelli Scarlets vsLeeds Carnegie, BBC Wales
Group D Sunday, Nov 4, 3pm, Saracens vs Bristol Rugby