Leicester Tigers fly-half Ford won his 70th Test cap from the bench in the win over Ireland last weekend after returning from injury and will start in the No10 shirt at Parc y Scarlets as England chase a hat-trick of Cup wins..
Youngs is in line for his 103rd England appearance, while Tigers colleague Ellis Genge is also included in the matchday squad after gaining a 21st cap in the win over the Irish.
The forward pack is unchanged for the last of the group-stage fixtures in the international tournament.
Head coach Eddie Jones said: “We’re expecting another tough match, and at the home of Welsh Rugby where the heart and soul of their game is.
“Twelve months ago, Wales were Grand Slam champions and three points from a World Cup Final, so we know what they are capable of.”
Wales versus England is live on Amazon Prime.
England (v Wales, away, Saturday 4.00pm)
15 Elliot Daly (Saracens, 45 caps)
14 Jonathan Joseph (Bath Rugby, 53 caps)
13 Henry Slade (Exeter Chiefs, 32 caps)
12 Owen Farrell (Saracens, 86 caps)
11 Jonny May (Gloucester Rugby, 59 caps)
10 George Ford (Leicester Tigers, 70 caps)
9 Ben Youngs (Leicester Tigers, 102 caps)
1 Mako Vunipola (Saracens, 62 caps)
2 Jamie George (Saracens, 52 caps)
3 Kyle Sinckler (Bristol Bears, 38 caps)
4 Maro Itoje (Saracens, 41 caps)
5 Joe Launchbury (Wasps, 67 caps)
6 Tom Curry (Sale Sharks, 26 caps)
7 Sam Underhill (Bath Rugby, 20 caps)
8 Billy Vunipola (Saracens, 54 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 24 caps)
17 Ellis Genge (Leicester Tigers, 21 caps)
18 Will Stuart (Bath Rugby, 6 caps)
19 Jonny Hill (Exeter Chiefs, 2 caps)
20 Ben Earl (Bristol Bears, 6 caps)
21 Jack Willis (Wasps, 1 cap)
22 Dan Robson (Wasps, 5 caps)
23 Anthony Watson (Bath Rugby, 44 caps)
Tigers hooker Shalva Mamukashvili returns to the Georgia front row for their third-round fixture against Ireland this Sunday.