The 26-year-old Kiwi starts at inside centre alongside Dan Hipkiss, with Ollie Smith moving to the right wing.
Tom Varndell occupies the other wing berth as he looks to continue an impressive recent run of form that has seen him register five tries in his last four appearances.
Benjamin Kayser retains his place at hooker against his French compatriots, while Marco Wentzel and Luke Abraham are named at lock and openside flanker respectively.
Seru Rabeni and Martin Castrogiovanni return to the replacements bench after missing the last three and two games respectively due to injury.
Tigers vs Toulouse, Welford Road, Saturday, December 8, kick-off 3.30pm
15 Sam Vesty
14 Ollie Smith
13 Dan Hipkiss
12 Aaron Mauger
11 Tom Varndell
10 Andy Goode
9 Frank Murphy
1 Marcos Ayerza
2 Benjamin Kayser
3 Julian White
4 Louis Deacon
5 Marco Wentzel
6 Martin Corry (captain)
7 Luke Abraham
8 Jordan Crane
Replacements
16 George Chuter
17 Martin Castrogiovanni
18 James Hamilton
19 Tom Croft
20 Ben Youngs
21 Johne Murphy
22 Seru Rabeni
