Wilkinson starts alongside James Grindall, with Tait occupying the full back berth and Long and Hayman packing down in the front row with Jon Golding.
Phil Dowson captains the side from the back row where he is joined by fellow England Saxons international Ben Woods, but England World Cup squad members Jamie Noon and Toby Flood both miss out with ankle injuries.
On the bench there could be a first Kingston Park appearance for back row Ross Beattie in his second spell at the club, while scrum half Hall Charlton returns to the 22 after recovering from a stomach injury.
In the first of two Guinness Premiership home games in the space of four days, acting director of rugby Steve Bates has made six changes from the side which faced Worcester Warriors in the European Challenge Cup last Friday.
Newcastle Falcons
15 Mathew Tait
14 Tom May
13 Tom Dillon
12 Tim Visser
11 John Rudd
10 Jonny Wilkinson
9 James Grindal
1 Jon Golding
2 Andy Long
3 Carl Hayman
4 Andy Perry
5 Andy Buist
6 Geoff Parling
7 Ben Woods
8 Phil Dowson (c)
Replacements
16 Rob Vickers
17 David Wilson
18 Ross Beattie
19 Russell Winter
20 Ed Williamson
21 Hall Charlton
22 Ollie Phillips
