Wayne Barnes will be the man on the whistle when Leicester Tigers travel to the Twickenham Stoop on Friday night.
Premiership Rugby's most experienced referee will take charge of his 216th league game in Tigers' Round 21 match against Harlequins this Friday, May 3 (7.45pm).
Craig Maxwell-Keys and JP Doyle will assist from the touchlines, while Television Match Official duties will be undertaken by Graham Hughes. The citing officer is Nick Wood.
Luke Pearce was the man in the middle when Tigers beat Harlequins 35-24 at Welford Road in the reverse fixture last December, while Barnes last took charge of a Leicester game in the Round 19 win away to Newcastle Falcons.