The match sees two of the most successful sides in European Cup history go head to head in a mouth-watering encounter in Pool 6 (kick-off 3.30pm).
Tigers won their last home game in the competition 39-0 against Edinburgh to put their campaign back on track following an opening-round defeat away to Leinster, and they know they must produce their best from against their visitors.
Toulouse head Pool 6 after wins over Edinburgh and Leinster in their opening fixtures and will be hoping for another good result on Saturday before the return fixture in the south of France on December 16.
Tigers set an attendance record for the pool stages of the EDF Energy Cup on Friday when a crowd of 17,172 witnessed the win over Sale Sharks. A new-look Clubhouse Stand has increased the capacity at Welford Road this season and another bumper crowd is expected for the visit of three-time European champions Toulouse.
Contact the Tigers ticket office now on 08701 28 34 30, book online at http://www.leicestertigers.com/ or call in at Welford Road.