Five Leicester Tigers players will kick off the Six Nations Championship in England colours in France on Sunday.
May joins Elliot Daly and newcomer George Furbank in the back three for the opening game of the Guinness Six Nations as Tuilagi joins captain Owen Farrell at centre.
Head coach Eddie Jones said: “It is the start of the Guinness Six Nations, the best rugby tournament in the world. We have had a great preparation in Portugal with a quality training week this week.
“We have picked a strong forward pack which is part of the England way and an exciting backline with young George Furbank playing his first Test at full-back.
“France can expect absolute brutality from England, we are going to go out there to make sure they understand what Test rugby is. It is about being brutal, it is about being physical and it is about dominating the set-piece.”
England (v France, Paris, Sunday 3pm UK time)
15 George Furbank (Northampton Saints, uncapped)
14 Jonny May (Leicester Tigers, 52 caps)
13 Manu Tuilagi (Leicester Tigers, 40 caps)
12 Owen Farrell (Saracens, 79 caps)(c)
11 Elliot Daly (Saracens, 39 caps)
10 George Ford (Leicester Tigers, 65 caps)
9 Ben Youngs (Leicester Tigers, 95 caps)
1 Joe Marler (Harlequins, 68 caps)
2 Jamie George (Saracens, 45 caps)
3 Kyle Sinckler (Harlequins, 31 caps)
4 Maro Itoje (Saracens, 34 caps)
5 Charlie Ewels (Bath Rugby, 12 caps)
6 Courtney Lawes (Northampton Saints, 81 caps)
7 Sam Underhill (Bath Rugby, 15 caps)
8 Tom Curry (Sale Sharks, 19 caps)
16 Luke Cowan-Dickie (Exeter Chiefs, 21 caps)
17 Ellis Genge (Leicester Tigers, 14 caps)
18 Will Stuart (Bath Rugby, uncapped)
19 George Kruis (Saracens, 41 caps)
20 Lewis Ludlam (Northampton Saints, 6 caps)
21 Willi Heinz (Gloucester Rugby, 9 caps)
22 Ollie Devoto (Exeter Chiefs, 1 cap)
23 Jonathan Joseph (Bath Rugby, 47 caps)
New France coach Fabien Galthie gives an international debut to Montpellier duo Anthony Bouthier and Mohamed Haouas, while the uncapped Cameron Woki and Boris Palu are among the replacements.
France: 15 Anthony Bouthier (Montpellier), 14 Teddy Thomas (Racing 92), 13 Virimi Vakatawa (Racing 92), 12 Gaël Fickou (Stade Français), 11 Damian Penaud (Clermont Auvergne), 10 Romain Ntamack (Toulouse), 9 Antoine Dupont (Toulouse); 1 Cyril Baille (Toulouse), 2 Julien Marchand (Toulouse), 3 Mohamed Haouas (Montpellier), 4 Bernard Le Roux (Racing 92), 5 Paul Willemse (Montpellier), 6 François Cros (Toulouse), 7 Charles Ollivon (Toulon) (c), 8 Grégory Alldritt (La Rochelle)
Replacements: 16 Peato Mauvaka (Toulouse), 17 Jefferson Poirot (Bordeaux-Bègles), 18 Demba Bamba (Lyon), 19 Boris Palu (Racing 92), 20 Cameron Woki (Bordeaux-Bègles), 21 Baptiste Serin (Toulon), 22 Matthieu Jalibert (Bordeaux-Bègles), 23 Vincent Rattez (La Rochelle)
There is live coverage of the game on BBC TV. Why not come to Welford Road and watch on the big screen in the Clubhouse with Tigers supporters during our opening Kegs and Eggs event of the year. Click here for details.
Places are available to enjoy unbeatable Tigers international hospitality for England’s home games against Ireland and Wales in the Six Nations. Click here for details.