Rain, snow and freezing conditions are forecast for Glasgow when the game kicks off at 7.45pm in what will be Thompstone’s first Saxons appearance.
There were similar conditions last season when Scotland A recorded a first-ever win in England with a 13-9 victory over the Saxons at Newcastle’s Kingston Park.
And Leicester Tigers winger Thompstone says the weather could play a big part in the game.
“The forecast is for snow but hopefully the weather forecasters have got that one wrong!” he said. “We are expecting it to be a very tough game. We’re expecting it to be pretty tough conditions but we have to adapt to them and face it head on.
“If the weather is going to be how it’s forecast then it won’t be a great day for the wingers. I’ll be looking to make sure I can do my bits well and to get involved in the game as much as I can. I’m really looking forward to it.”
Thompstone was recovering at home on Sunday after the LV= Cup trip to Harlequins when he received the call-up to the Saxons squad.
He said: “I was not expecting to get the call so it was a surprise. I went into Tigers on the Monday to do some weights before meeting up with the squad at Loughborough in the afternoon.
“Everyone at Oval Park wished me good luck and stuff and now I can’t wait to get going.”
Kyle Eastmond, who won senior caps in Argentina last summer, and Semesa Rokoduguni (both Bath Rugby) and Dan Robson (Gloucester Rugby) also make their first Saxons starts alongside Thompstone in the backline.
There are four changes to the forwards with Dave Ward (Harlequins), Scott Wilson (Newcastle Falcons), Elliott Stooke (Gloucester Rugby) and Sam Dickinson (Northampton Saints) - all second half replacements in Saxons' 14-8 defeat at the hands of the Ireland Wolfhounds at Kingsholm last Saturday - making their first starts.
15 Rob Miller (Sale Sharks)
14 Semesa Rokoduguni (Bath Rugby)
13 Elliot Daly (London Wasps)
12 Kyle Eastmond (Bath Rugby)
11 Adam Thompstone (Leicester Tigers)
10 Freddie Burns (Gloucester Rugby)
9 Dan Robson (Gloucester Rugby)
1 Alex Waller (Northampton Saints)
2 Dave Ward (Harlequins)
3 Scott Wilson (Newcastle Falcons)
4 Elliott Stooke (Gloucester Rugby)
5 George Kruis (Saracens)
6 Calum Clark (Northampton Saints, Captain)
7 Luke Wallace (Harlequins)
8 Sam Dickinson (Northampton Saints)
16 Jamie George (Saracens)
17 Nathan Catt (Bath Rugby)
18 Kieran Brookes (Newcastle Falcons)
19 Charlie Matthews (Harlequins)
20 Dave Ewers (Exeter Chiefs)
21 Joe Simpson (London Wasps)
22 Henry Slade (Exeter Chiefs)
23 Charlie Sharples (Gloucester Rugby)
Note: You can watch Scotland A v England Saxons streamed live online at rfu.com on Friday night.