The game kicks off in Rosario, Argentina at 8.45pm today (Monday) and is live on Sky Sports 3.
Head coach Mark Mapletoft said: “This is a good chance for the whole squad to end the tour on a high.
“We've looked at all the South African games. They've clearly had a change of emphasis from last year and previous years. They are very comfortable ball-in-hand, they've got some exciting runners and they combine ambition with some traditional South African forward play which we will need to combat to ensure we maintain dominance throughout the game.”
England U20
15 Tom Homer (London Irish)
14 Christian Wade (London Wasps)
13 Jonny May (Gloucester)
12 Tom Casson (Harlequins)
11 Marcus Watson (London Irish)
10 Freddie Burns (Gloucester)
9 Sam Harrison (Leicester Tigers)
1 Joe Marler (Harlequins)
2 Jamie George (Saracens)
3 Mako Vunipola (Bristol)
4 Calum Green (Leicester Tigers)
5 George Kruis (Saracens)
6 Will Welch (Newcastle Falcons)
7 Jacob Rowan (Leeds Carnegie, captain)
8 Jamie Gibson (London Irish)
Replacements
16 Rob Buchanan (Harlequins)
17 Shaun Knight (Gloucester)
18 Charlie Matthews (Harlequins)
19 Alex Gray (Newcastle Falcons)
20 Charlie Davies (Stade Francais)
21 Rory Clegg (Harlequins)
22 Sam Smith (Harlequins)