Eddie Jones has named Genge at loosehead prop for his 20th Test cap, with Ben Youngs moving on to 101 caps at scrum-half in the Quilter International at Twickenham in the first game since winning the Guinness Six Nations last month.
Elsewhere in the team, Jack Willis makes his England debut at flanker, Will Stuart makes his first start at tighthead and Ollie Lawrence, who made his England debut in the win over Italy two weeks ago, is at outside centre. Max Malins could make his first England appearance after being included on the bench.
Head coach Jones said: “We’ve had a really good week of training. We know there are a lot of expectations on us and we’ve applied ourselves hard and put a lot of pressure on ourselves in the early part of this week.
“Georgia will be a tough opponent, so we have a team with some real power in midfield. We have a good mix of youth and experience across the squad and they are completely focused on putting in an excellent performance on Saturday.
“We’re looking forward to being back at our home at Twickenham, we are humbled by the opportunity and want to give people a reason to smile during such a tough time for the country.”
England versus Georgia is live on Amazon Prime and BBC Radio 5 Live. Kick-off is at 3.00pm.
15 Elliot Daly (Saracens, 43 caps)
14 Jonathan Joseph (Bath Rugby, 51 caps)
13 Ollie Lawrence (Worcester Warriors, 1 cap)
12 Henry Slade (Exeter Chiefs, 30 caps)
11 Jonny May (Gloucester Rugby, 57 caps)
10 Owen Farrell (Saracens, 83 caps) (c)
9 Ben Youngs (Leicester Tigers, 100 caps)
1 Ellis Genge (Leicester Tigers, 19 caps)
2 Jamie George (Saracens, 50 caps)
3 Will Stuart (Bath Rugby, 4 caps)
4 Charlie Ewels (Bath Rugby, 16 caps)
5 Joe Launchbury (Wasps, 65 caps)
6 Maro Itoje (Saracens, 39 caps)
7 Jack Willis (Wasps, uncapped)
8 Billy Vunipola (Saracens, 52 caps)
16 Tom Dunn, (Bath Rugby, 1 cap)
17 Mako Vunipola (Saracens, 60 caps)
18 Kyle Sinckler (Bristol Bears, 36 caps)
19 Ben Earl (Bristol Bears, 4 caps)
20 Tom Curry (Sale Sharks, 24 caps)
21 Dan Robson (Wasps, 3 caps)
22 Max Malins (Bristol Bears, uncapped)
23 Joe Marchant (Harlequins, 3 caps)