Having topped the Northern Conference, Tigers travel to Henley to face southern champions Wasps, with the game kicking-off at 7.30pm.
The return leg has been scheduled for Monday May 7 at Welford Road (kick-off 7pm).
All seven members of the backline have been included in the first-team matchday squad at sometime this season, while the forward pack boasts a similar degree of experience.
Former England U-21 captain Matt Cornwell skippers the side from inside centre, with Johne Murphy, Leon Lloyd and Ian Humphreys also included.
An impressive-looking back row features Henry Tuilagi, Luke Abraham and Jordan Crane, while James Buckland and James Hamilton also start for the twice A League winners.
Tigers
15 Johne Murphy
14 Leon Lloyd
13 Matt Cornwell ( C )
12 Tom Youngs
11 Ollie Dodge
10 Ian Humphreys
9 Ben Youngs
1 Michael Holford
2 James Buckland
3 Dan Cole
4 James Hamilton
5 Ian Nimmo
6 Henry Tuilagi
7 Luke Abraham
8 Jordan Crane
Replacements
Greg Sammons
Matt Parr
Ben Herring
Ben Pienaar
Alex Shaw
Matt Smith
Greig Tonks