The reigning Guinness Premiership champions travel to Kingston Park to face Newcastle Falcons knowing that a victory is imperative if they are to have any chance of making the league's top four.
I'm looking forward to the game, says Tuilagi. It's a really tough situation for us but we're still confident.
We need to win these next two games to have a chance of making our way to a semi-final and, hopefully, a final. It's a big chance for us.
The Samoan who started Tigers' last Premiership fixture, a 32-14 win over Bristol at Welford Road, has been named in a back three that also includes fellow internationals Tom Varndell and Geordan Murphy for the must-win clash with Newcastle.
That bonus-point win a fortnight ago saw Tuilagi make his sixth start in eight games following his return from injury on March 1 and the 27-year-old is keen for Tigers to put in a repeat performance.
The team played well against Bristol and the whole team is looking forward to a big chance like this. It's coming to the end of the season and we want to achieve something. We want to defend the trophy for the club. Everybody is looking forward to the last two games and you can see that in training.