Marco Wentzel returns to the second row after injury, while Benjamin Kayser gets the nod at hooker.
Wentzel’s selection means a return to the back row for skipper Martin Corry for the penultimate league game of the season.
“We know exactly what we need to do in the last two games of the season,” said Loffreda. “We will travel with a positive attitude but we know we will have to play very well.
“The players had a few extra days off last week when we did not have a game, but then we came back to prepare for the two massive games against Newcastle and Harlequins.”
Ben Herring is ruled out by injury, while Johne Murphy also sits this one out after suffering a knee injury in the match at Bath two weeks ago.
Leicester Tigers (versus Newcastle Falcons away, Sunday 3pm)
15 Geordan Murphy
14 Tom Varndell
13 Dan Hipkiss
12 Aaron Mauger
11 Alesana Tuilagi
10 Andy Goode
9 Harry Ellis
1 Martin Castrogiovanni
2 Benjamin Kayser
3 Julian White
4 Marco Wentzel
5 Ben Kay
6 Martin Corry (c)
7 Tom Croft
8 Jordan Crane
Replacements
16 Mefin Davies
17 Marcos Ayerza
18 Richard Blaze
19 Brett Deacon
20 Christophe Laussucq
21 Sam Vesty
22 Ayoola Erinle
Injured: Luke Abraham, Louis Deacon, James Hamilton, Ben Herring, Lewis Moody, Johne Murphy
Suspended: Seru Rabeni
