Dan Hipkiss will gain his eighth cap at centre and Louis Deacon earns his ninth after being named in the second row.
Vesty is included among the replacements alongside Ben Kay, Jordan Crane and Julian White, who is in line for his 50th cap.
England team manager Martin Johnson gives a debut to wing Matt Banahan, prop David Wilson and centre Tom May.
Tickets for England v Argentina in The Standard Bank Cup are priced from £10 adults and £1 under-16s and are available by calling 0161 868 8000 (option 9) or contacting www.manutd.com. Tickets will also be available from Old Trafford on the day of the game.
England (v Argentina, Old Trafford, Saturday 4pm)
15 Delon Armitage (London Irish)
14 Mark Cueto (Sale Sharks)
13 Dan Hipkiss (Leicester Tigers)
12 Tom May (Newcastle Falcons)
11 Matt Banahan (Bath Rugby)
10 Andy Goode (CA Brive)
9 Danny Care (Harlequins)
1 Tim Payne (London Wasps)
2 Dylan Hartley (Northampton Saints)
3 David Wilson (Newcastle Falcons)
4 Steve Borthwick (Saracens, captain)
5 Louis Deacon (Leicester Tigers)
6 James Haskell (London Wasps)
7 Steffon Armitage (London Irish)
8 Nick Easter (Harlequins)
Replacements
16 Steve Thompson (CA Brive)
17 Julian White (Leicester Tigers)
18 Ben Kay (Leicester Tigers)
19 Jordan Crane (Leicester Tigers)
20 Paul Hodgson (London Irish)
21 Sam Vesty (Leicester Tigers)
22 Mathew Tait (Sale Sharks)
