Julián Montoya led Argentina to a famous 30-29 victory over England at Twickenham on Sunday, the fifth win of the calendar year for Los Pumas in ten Tests and the first over the home nation at their home ground in 16 years.
The Argentine's have now defeated Scotland (twice), New Zealand and Australia, and now England, in 2022.
England took a four-point lead into half-time in London, however, two quick tries from Los Pumas in the opening 10 minutes of the second-half saw them break away.
The home side fought their way back to a winning position but, with less than 10 minutes, remaining a penalty-goal for Argentina put them a point in front - where they remained through a disciplined, defensive effort in the dying stages.
Elsewhere in the opening weekend of Autumn Test fixtures, it was a disappointing weekend for Tigers in action on the international stage.
Tommy Reffell and his Welsh team-mates were convincingly defeated by New Zealand 55-23 in Cardiff, Kini Murimurivalu and Fiji went down to Scotland 28-12 in Edinburgh, Nephi Leatigaga came off the bench in Samoa's 49-17 loss to Italy and Jasper Wiese suffered defeat with South Africa to Ireland, 19-16, in Dublin.