Jack van Poortvliet, Guy Porter and Freddie Steward will start for England in their Autumn Test against Japan at Twickenham on Saturday, Novemnber 12.
The Leicester Tigers trio are joined by clubmates Joe Heyes and Ben Youngs, who are named among the replacements, in the matchday squad.
The Test will be the first start for both van Poortvliet and Porter at home, with Porter set for his first international appearance at Twickenham.
Starting XV: 15. Freddie Steward, 14. Jack Nowell (vc), 13. Guy Porter, 12. Owen Farrell (c), 11. Jonny May, 10. Marcus Smith, 9. Jack van Poortvliet; 1. Ellis Genge (vc), 2. Luke Cowan-Dickie, 3. Kyle Sinckler, 4. David Ribbans, 5. Jonny Hill , 6. Maro Itoje, 7. Tom Curry, 8. Sam Simmonds
Finishers: 16. Jamie George , 17. Mako Vunipola, 18. Joe Heyes, 19. Alex Coles , 20. Billy Vunipola, 21. Ben Youngs, 22. Henry Slade, 23. Manu Tuilagi