Tigers won 15-10 at Franklin's Gardens earlier in the season and are quoted at 1/10 to follow up with another victory.
Coral.co.uk, the official betting and gaming partner of Premier Rugby and the Guinness Premiership, quote Saints at 5/1. The draw is a 25/1 bet.
Have you opened a Coral.co.uk account yet? Visit www.coral.co.uk/rugby for all the betting odds on this weekend's games in the Guinness Premiership and RBS 6 Nations.
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This weekend's odds with www.Coral.co.uk
Sale 8/13 London Irish 5/4. draw 18/1
Newcastle 10/11 v Wasps 10/11. draw 16/1
Leicester 1/10 v Northampton 5/1. draw 25/1
Bath 10/11 v Saracens 10/11. draw 16/1
Gloucester 1/7 v Worcester 4/1. draw 25/1
Harlequins 4/5 v Bristol evens. draw 16/1