The venue switch comes as a result of Notts County’s home draw in the FA Cup against Bradford City that weekend, which also sees Nottingham Forest take on Bristol City.
Leicester Tigers have stepped in to help The Green and Whites with the fixture headache.
Nottingham director of rugby Glenn Delaney said: “Leicester and Nottingham have enjoyed a friendly rivalry as neighbours over many seasons and have also forged a very successful relationship in recent years.
“We’re delighted that Leicester Tigers are in a position to allow us to play our next home game at Welford Road and we are very grateful for that support.
“The enthusiasm for rugby in Leicester is enormous and we hope some of those supporters will come and see what we are all about.
“Welford Road is one of the best, if not the best rugby ground in England and it will be really good to see a good crowd down there.
“It’s an exciting opportunity for us and we really want Nottingham to get behind us in what should be a top-of-the-table clash.
“There should be some really exciting rugby played and we want as many people to enjoy that as possible.
"We want to see as many of our fans down there as possible and we are looking into ways of helping people to get to the game to make it as easy as possible.”
Chiefs lead the table, with Nottingham just eight points behind in third place so Saturday's clash is crucial for both sides and should provide an attractive prospect for Midlands rugby supporters.
Kick-off is at 4.15pm and supporters can watch big-screen coverage of England v Australia from 2.30pm and enjoy a full afternoon’s rugby at Welford Road.
For ticket details, contact Nottingham Rugby by calling 0115 907 0070 or book online at www.nottinghamrugbyshop.com
Tickets will be available on the day.