Leicester Tigers forwards Tom Croft and Julian White have been selected on the bench for the game at Twickenham on Saturday (kick-off 3pm).
London Irish flanker Steffon Armitage is handed his debut on the openside with his brother Delon at full-back.
Former Tigers player Andy Goode is named at fly-half, while the team will be captained from the second-row by Steve Borthwick.
England
15 Delon Armitage (London Irish)
14 Paul Sackey (London Wasps)
13 Mike Tindall (Gloucester Rugby)
12 Riki Flutey (London Wasps)
11 Mark Cueto (Sale Sharks)
10 Andy Goode (Brive)
9 Danny Care (Harlequins)
1 Andrew Sheridan (Sale Sharks)
2 Lee Mears (Bath Rugby)
3 Phil Vickery (London Wasps)
4 Steve Borthwick (Saracens, captain)
5 Nick Kennedy (London Irish)
6 James Haskell (London Wasps)
7 Steffon Armitage* (London Irish)
8 Nick Easter (Harlequins)
Replacements
16 Dylan Hartley (Northampton Saints)
17 Julian White (Leicester Tigers)
18 Tom Croft (Leicester Tigers)
19 Joe Worsley (London Wasps)
20 Ben Foden (Northampton Saints)
21 Shane Geraghty (London Irish)
22 Mathew Tait (Sale Sharks)
* Denotes new cap
