Croft scored a try in last Wednesday’s win over the Golden Lions and will be hoping for another eye-catching display in the fourth game of the tour to South Africa.
Lions tour manager Gerald Davies said: "We are halfway through the provincial matches prior to the first Test and the important factor is that the Lions are unbeaten. The team will want to ensure that the 100-per-cent record is maintained with a victory at ABSA Stadium which is also the venue of the first Test."
The Lions face matches against two of South Africa's strongest provinces in the Sharks and Western Province in the space of four days as they build up towards the Test series.
Wednesday’s game is to be shown live by Sky Sports. Big-screen coverage will be shown in the ABC Bar at Tigers’ Welford Road stadium.
British & Irish Lions (vs Sharks, Wednesday, 6.10pm)
15 Lee Byrne (Ospreys/Wales)
14 Shane Williams (Ospreys/Wales)
13 Brian O'Driscoll (Leinster/Ireland)
12 Jamie Roberts (Cardiff Blues/Wales)
11 Luke Fitzgerald (Leinster/Ireland)
10 Ronan O'Gara (Munster/Ireland)
9 Mike Phillips (Ospreys/Wales)
1 Gethin Jenkins (Cardiff Blues/Wales)
2 Lee Mears (Bath/England)
3 Adam Jones (Ospreys/Wales)
4 Alun-Wyn Jones (Ospreys/Wales)
5 Paul O'Connell (Munster/Ireland) captain
6 Tom Croft (Leicester Tigers/England)
7 David Wallace (Munster/Ireland)
8 Jamie Heaslip (Leinster/Ireland)
16 Matthew Rees (Scarlets/Wales)
17 Phil Vickery (London Wasps/England)
18 Simon Shaw (London Wasps/England)
19 Joe Worsley (London Wasps/England)
20 Mike Blair (Edinburgh/Scotland)
21 Riki Flutey (London Wasps/England)
22 Leigh Halfpenny (Cardiff Blues/Wales)