The Tigers old boys, with Richard Cockerill, Darren Garforth and Dorian West among those set to don their playing boots again, are taking on a team from Leicestershire Police at Oval Park.
Last year's fixture attracted a bumper crowd and raised £5,000 for the Matt Hampson Foundation.
"There are causes you try to turn out for occasionally, particularly the Matt Hampson Foundation," said Cockerill who played in last year's fixture and shared in a recent England Legends game against their Irish counterparts.
Kick-off is at 2pm and entry is £5 per family on the day.
Oval Park is in Wigston Road, Oadby.