Miles Benjamin, Jamie Gibson, Graham Kitchener and Mathew Tait all miss out on the game at Gloucester’s Kingsholm on Saturday (5pm).
Benjamin missed the game against Ulster Rugby with a knee injury while Gibson, Kitchener and Tait all picked up knocks in the Heineken Cup clash.
Gloucester lock Elliot Stooke replaces Kitchener and Sale full-back Rob Miller comes in for Tait. No replacements have been called up in place of Benjamin and Gibson, who will be reassessed at the end of the week with a view to being available for the match against Scotland A in Glasgow on January 31.
The Saxons have also added Harlequins centre Matt Hopper and Northampton Saints prop Tom Mercey for Bath Rugby’s Jonathan Joseph and Harlequins’ Will Collier.
Nathan Catt (Bath Rugby)
Calum Clark (Northampton Saints)
Sam Dickinson (Northampton Saints)
Dave Ewers (Exeter Chiefs)
Jamie George (Saracens)
George Kruis (Saracens)
Charlie Matthews (Harlequins)
Tom Mercey (Northampton Saints)
Elliott Stooke (Gloucester Rugby)
Luke Wallace (Harlequins)
Alex Waller (Northampton Saints)
Dave Ward (Harlequins)
Scott Wilson (Newcastle Falcons)
Freddie Burns (Gloucester Rugby)
Elliot Daly (London Wasps)
Sam Hill (Exeter Chiefs)
Matt Hopper (Harlequins)
Dave Lewis (Exeter Chiefs)
Rob Miller (Sale Sharks)
Joe Simpson (London Wasps)
Henry Slade (Exeter Chiefs)
Semesa Rokoduguni (Bath Rugby)
Tom Varndell (London Wasps)