Eddie Jones has made four changes to his England side for Sunday's RBS 6 Nations game against Italy at Twickenham Stadium (3.00pm, live on ITV).
Ben Te’o gets his first start in an England shirt at outside-centre, while Danny Care replaces Ben Youngs at scrum-half. Jonny May returns to the right wing and James Haskell is at flanker.
Mako Vunipola returns to the matchday 23 for the first time this year having recovered from a knee injury. Dan Cole is retained at tighthead and wins a 72nd cap.
Owen Farrell win his 50th cap for England having made his debut against Scotland at Murrayfield in 2012.
“We have had a good two-week preparation and we’re ready to go,” said head coach Jones.
“Selection was tough. Ben Te’o at 13 gives us another way of playing the game and we are excited about seeing him, George Ford and Owen Farrell play together in the midfield.
“Ben Youngs has been outstanding for us at number nine, but Danny Care gets the starting jersey this week. For the first half he’ll give us a lot of speed and running at the base of the ruck as well as the scrum. Ben will then come on and finish the game.
“Tom Wood has been great for us at seven, and Jack Clifford did well against Wales but James Haskell has the starting role on Sunday; he has come back to a much better level of fitness and we are sure his explosive actions will help us in the first part of the game.
“It is an important Test match for us and our only consideration is to play well. Italy have a proud record in Test rugby, they beat South Africa in November, and we will not underestimate them.”
England team (v Italy, Sunday 3.00pm)
15 Mike Brown (Harlequins, 57 caps)
14 Jonny May (Gloucester Rugby, 24 caps)
13 Ben Te’o (Worcester Warriors, 5 caps)
12 Owen Farrell (Saracens, 49 caps)
11 Elliot Daly (Wasps, 10 caps)
10 George Ford (Bath Rugby, 32 caps)
9 Danny Care (Harlequins, 68 caps)
1 Joe Marler (Harlequins, 48 caps)
2 Dylan Hartley (Northampton Saints, 81 caps)(c)
3 Dan Cole (Leicester Tigers, 71 caps)
4 Joe Launchbury (Wasps, 39 caps)
5 Courtney Lawes (Northampton Saints, 55 caps)
6 Maro Itoje (Saracens, 9 caps)
7 James Haskell (Wasps, 72 caps)
8 Nathan Hughes (Wasps, 5 caps)
Replacements
16 Jamie George (Saracens, 14 caps)
17 Mako Vunipola (Saracens, 39 caps)
18 Kyle Sinckler (Harlequins, 5 caps)
19 Tom Wood (Northampton Saints, 47 caps)
20 Jack Clifford (Harlequins, 9 caps)
21 Ben Youngs (Leicester Tigers, 67 caps)
22 Henry Slade (Exeter Chiefs, 4 caps)
23 Jack Nowell (Exeter Chiefs, 20 caps)
Ben Te’o gets his first start in an England shirt at outside-centre, while Danny Care replaces Ben Youngs at scrum-half. Jonny May returns to the right wing and James Haskell is at flanker.
Mako Vunipola returns to the matchday 23 for the first time this year having recovered from a knee injury. Dan Cole is retained at tighthead and wins a 72nd cap.
Owen Farrell win his 50th cap for England having made his debut against Scotland at Murrayfield in 2012.
“We have had a good two-week preparation and we’re ready to go,” said head coach Jones.
“Selection was tough. Ben Te’o at 13 gives us another way of playing the game and we are excited about seeing him, George Ford and Owen Farrell play together in the midfield.
“Ben Youngs has been outstanding for us at number nine, but Danny Care gets the starting jersey this week. For the first half he’ll give us a lot of speed and running at the base of the ruck as well as the scrum. Ben will then come on and finish the game.
“Tom Wood has been great for us at seven, and Jack Clifford did well against Wales but James Haskell has the starting role on Sunday; he has come back to a much better level of fitness and we are sure his explosive actions will help us in the first part of the game.
“It is an important Test match for us and our only consideration is to play well. Italy have a proud record in Test rugby, they beat South Africa in November, and we will not underestimate them.”
England team (v Italy, Sunday 3.00pm)
15 Mike Brown (Harlequins, 57 caps)
14 Jonny May (Gloucester Rugby, 24 caps)
13 Ben Te’o (Worcester Warriors, 5 caps)
12 Owen Farrell (Saracens, 49 caps)
11 Elliot Daly (Wasps, 10 caps)
10 George Ford (Bath Rugby, 32 caps)
9 Danny Care (Harlequins, 68 caps)
1 Joe Marler (Harlequins, 48 caps)
2 Dylan Hartley (Northampton Saints, 81 caps)(c)
3 Dan Cole (Leicester Tigers, 71 caps)
4 Joe Launchbury (Wasps, 39 caps)
5 Courtney Lawes (Northampton Saints, 55 caps)
6 Maro Itoje (Saracens, 9 caps)
7 James Haskell (Wasps, 72 caps)
8 Nathan Hughes (Wasps, 5 caps)
Replacements
16 Jamie George (Saracens, 14 caps)
17 Mako Vunipola (Saracens, 39 caps)
18 Kyle Sinckler (Harlequins, 5 caps)
19 Tom Wood (Northampton Saints, 47 caps)
20 Jack Clifford (Harlequins, 9 caps)
21 Ben Youngs (Leicester Tigers, 67 caps)
22 Henry Slade (Exeter Chiefs, 4 caps)
23 Jack Nowell (Exeter Chiefs, 20 caps)
