After last weekend's 15-try demolition of Spanish champions Cetransa El Salvador, director of rugby John Fletcher has made a number of changes, including the recall of New Zealand prop Carl Hayman, former Tigers scrum-half James Grindal and Wilkinson.
Asked what he can expect from Saturday’s game, Fletcher said: "You know what you're going to get with Leicester, and it's just a case of can you get yourself in to the game, can you get enough ball to impose your style and can you get enough points to be in with a shout of winning it with 10 or 15 minutes to go.
"We had a big hiding down there a few years ago which was massively embarrassing for us, but since then we've drawn at Welford Road and beaten them a couple of times up here.
"We beat them pretty comfortably at second-team level a fortnight ago and, while we do respect them, I wouldn't say we fear them. I'm sure the same applies if you ask their coach about us, because you're dealing with two good teams."
Newcastle Falcons team (v Leicester Tigers, at Welford Road, Saturday 3pm)
15 Mathew Tait
14 Tom May
13 Jamie Noon (captain)
12 Toby Flood
11 John Rudd
10 Jonny Wilkinson
9 James Grindal
1 Jon Golding
2 Andy Long
3 Carl Hayman
4 Andy Perry
5 Mark Sorenson
6 Brent Wilson
7 Ben Woods
8 Russell Winter
Replacements
16 Matt Thompson
17 Micky Ward
18 Geoff Parling
19 Phil Dowson
20 Lee Dickson
21 Tim Visser
22 Ollie Phillips
