England team manager Martin Johnson has made three changes to the team, with Flood at fly-half, Nick Kennedy coming in at lock and Michael Lipman named at openside flanker.
Flood’s Tigers colleagues Tom Croft, Harry Ellis and Dan Hipkiss are among the replacements.
Flood, Croft and Ellis have been involved in all three autumn internationals so far, while Hipkiss is called into the matchday 22 for the first time in the Investec Challenge series.
Leicester Tigers head coach Heyneke Meyer said: “I am very happy for all of the guys involved, and happy that Toby has been given a starting spot. He has been playing well for us this season. It is good to see Danny in there too this time, he has been playing well.”
Live coverage of the England game will be screened in the ABC Bar at Welford Road. Kick-off is at 2.30pm on Saturday.
England team (v New Zealand, Saturday)
15 Delon Armitage (London Irish)
14 Paul Sackey (London Wasps)
13 Jamie Noon (Newcastle Falcons)
12 Riki Flutey (London Wasps)
11 Ugo Monye (Harlequins)
10 Toby Flood (Leicester Tigers)
9 Danny Care (Harlequins)
1 Tim Payne (London Wasps)
2 Lee Mears (Bath Rugby)
3 Phil Vickery (London Wasps)
4 Steve Borthwick (Saracens, captain)
5 Nick Kennedy (London Irish)
6 James Haskell (London Wasps)
7 Michael Lipman (Bath Rugby)
8 Nick Easter (Harlequins)
16 Dylan Hartley (Northampton Saints)
17 Matt Stevens (Bath Rugby)
18 Tom Croft (Leicester Tigers)
19 Tom Rees (London Wasps)
20 Harry Ellis (Leicester Tigers)
21 Danny Cipriani (London Wasps)
22 Dan Hipkiss (Leicester Tigers)