Leicester Tigers fly-half Ford landed five penalties and four conversions in a perfect kicking display and also helped to control the game for England.
Second row Sam Twomey scored two tries, with flanker Billy Vunipola adding a third and centre Elliott Daly adding a fourth from the final move of the match
Ford controlled England's revival from 16-7 down early in the second half with a superb kicking display, successful with all nine shots at goal for a 23-point individual haul.
"We wanted to go out and score tries and, while we got one early on, we just couldn't get in the right field position after that," Ford said.
"In the second half we really came out of the blocks and scored three good tries, and to score 40 points against Wales is a massive effort. Sometimes it doesn't always come off. We try and play with ambition and we all buy into that.
"I kicked all right today but fair play for the boys for getting me in the right positions."
Ford has already led England Under-18s to victories over Australia Schools, France and Italy this year, and the squad will look to add to that record when they meet Ireland and Scotland in the next fortnight.
Wales Under 18: Tom Prydie (Ospreys); Harry Robinson (Blues), George North (Scarlets), Luke Williams (Scarlets), Eli Walker (Ospreys); Matthew Morgan (Ospreys), Jonathan Evans (Dragons); Daan Harris (Blues), Kirby Myhill (Scarlets), Will Griff John (Blues), Cory Hill (Blues), Luke Hamilton (Scarlets), Owen Sheppeard (Blues), Thomas Young (Blues, Captain), Dan Baker (Ospreys).
Replacements: Jack Dando (Blues) for Myhill 54, Rob Evans (Scarlets) for Harris 47, Samson Lee (Scarlets) for John 52, Matthew Screech (Blues) for Baker 66, Ellis Jenkins (Blues) for Sheppeard 54, Tom Habberfield (Ospreys) for Evans 54, Joseff Griffin (Blues) for Morgan 68, Sam Campbell (Blues) for Robinson 68.
Scorers: Try: Williams. Conversion: Morgan. Penalties: Morgan 5.
England Under-18: Ben Ransom (Tonbridge & Saracens); Marland Yarde (Whitgift & London Irish), Elliot Daly (Whitgift & London Wasps), Ryan Mills (Hartpury Coll & Gloucester), Charlie Walker (Oakham); George Ford (Rishworth & Leicester Tigers, captain), Joel Hodgson (RGS Newcastle & Newcastle Falcons); Nick Auterac (Oaklands College & Saracens), Koree Britton (Ivybridge Coll & Exeter Chiefs), Anthony Brennan (Twyford CofE & London Wasps), Dominic Barrow (Prince Henry's GS Otley & Leeds Carnegie), Sam Twomey (Dulwich Coll & Harlequins), Billy Vunipola (Harrow & London Wasps), Will Skuse (Bryanston & Bath Rugby), Matt Kvesic (Worcester Sixth Form Coll & Worcester Warriors)
Replacements: Nathan Moris (Sedbergh & Newcastle Falcons) for Britton 60, Luke Cowan-Dickie (Truro Coll & Exeter Chiefs) for Auterac 41, Kyle Sinckler (Epsom Coll & Harlequins) for Brennan 68, George Merrick (Whitgift & Harlequins) for Barrow 68, Dan Robson (Hartpury Coll & Gloucester Rugby) for Hodgson 52, Chris Elder (RGS High Wycombe & London Wasps) for Yarde 68, Mark Jennings (Lymm HS & Sale Sharks) for Charlie Walker 54.
Scorers: Tries: Twomey 2, Vunipola, Daly. Conversions: Ford 4. Penalties: Ford 5.